Performance Enhancement Strategies for Low Solubility APIs – do more with less

3/17/2021 10:25 - 11:00

This presentation will address the main challenges in the formulation of ASDs, and highlighting the importance of integrated development and the synergies between pre-formulation and commercial manufacturing expertise. The science-based development platform for ASDs will be presented. This platform relies on the integration between formulation and analytical development, from API to drug product, coupled with the use of computational models, formulation databases and miniaturized high-throughput in vitro techniques.

Here we will also present how the use of state-of-the-art, automated, spray drying equipment, coupled with in-silico formulation tools enable a high-throughput screening (HTS) approach for the development of ASDs.

Mafalda Paiva, Group Leader, R&D Analytical Development, Hovione

João Henriques, Group Leader, R&D Drug Product Development, Hovione