Material Properties of Amorphous Solid Dispersions – Influence of Incorporated Drugs

Formulation development of amorphous solid dispersions (ASD) still is challenging although the technology is established and several poorly water-soluble drugs have been marketed using this technique
Selection of excipients for ASDs needed for tablet compression is often performed on a case-by-case basis according to the formulator’s experience and eventually trial and error
As the polymer is the main component in the ASD, it predominantly determines material properties and thus systematically investigating the impact of the incorporated drug on these properties (e.g. mechanical properties and wetting behavior) helps rationalizing and facilitating excipient selection