Material Properties of Amorphous Solid Dispersions – Influence of Incorporated Drugs

3/17/2021 09:45 - 10:20

  • Formulation development of amorphous solid dispersions (ASD) still is challenging although the technology is established and several poorly water-soluble drugs have been marketed using this technique
  • Selection of excipients for ASDs needed for tablet compression is often performed on a case-by-case basis according to the formulator’s experience and eventually trial and error
  • As the polymer is the main component in the ASD, it predominantly determines material properties and thus systematically investigating the impact of the incorporated drug on these properties (e.g. mechanical properties and wetting behavior) helps rationalizing and facilitating excipient selection

Karsten Fluegel, Postdoctoral Researcher | Drug Delivery & Innovation, Merck