A Self-Assembly Multifunctional Platform for Therapeutic Delivery of Nucleic Acid Medicines to the Brain

3/17/2021 09:45 - 10:20

A peptidic phage mimetic self-assembly (termed NanoLigand Carriers, NLCs) will be presented capable of rapidly crossing the intact blood-brain barrier (BBB) on intravenous injection in substantial quantities, and without disrupting the integrity of the BBB (Nature Communications 2019, 10:4635). The system accommodates a wide range of guest molecules, and targets two cellular receptors. On reaching the brain-parenchyma, NLCs carrying therapeutic nucleic acids target microglial cells and neurons showing unprecedented pharmacological effects and without inducing inflammation and metabolic perturbations.

Moein Moghimi, Professor of Nanomedicine, Newcastle University