The Boon and Bane of Polysorbate

3/16/2021 08:50 - 09:25

Polysorbate 20 and 80 , also known as Tween, are the most used excipients for the stabilisation of biologics, due to specific beneficial properties. About 90% of commercialised biologics contain polysorbate. A number of vaccines too.

In the past, however, observations were published showing, that polysorbate may degrade and may be involved in the formation of particles. According to publications, this issue seems to be observed very broadly. The current talk summarises the current knowledge about polysorbate degradation pathways, analytics, quality, application etc.

Patrick Garidel, Head of Process, Purification and Pharma Development, Boehringer Ingelheim