Spray Drying Formulations with HPMCAS (Hypromellose Acetate Succinate)

3/16/2021 10:10 - 10:45

HPMCAS (Shin-Etsu AQOAT®) is the most popular excipient for amorphous solid dispersion formulation due to its unique properties of improving solubility, maintaining supersaturation, and good stability of the drug product.

In this presentation, we investigate the Spray Drying Formulations with HPMCAS both in spray drying process and downstream process.

  • Spray Drying Formulations with HPMCAS (Hypromellose Acetate Succinate) as Carrier Polymer: Impact of process parameters to powder properties
  • Downstream processing of HPMCAS spray dried dispersion. Head to head comparison of L-HPC (low-substituted hydroxypropyl cellulose) as binder and disintegrant and MCC/croscarmellose blends

Shogo Warashina, Technical Sales Manager, SE Tylose GmbH & Co.KG