Hydroxypropyl-β-cyclodextrin as a Versatile Excipient in Biologics Processes – Application in Ultrafiltration/Diafiltration

3/16/2021 12:15 - 12:50

  • Biologics undergo various stresses during manufacturing, transport and storage.
  • HPβCD has been successfully used to mitigate aggregation in biologic formulations.
  • HPβCD is surface active and can potentially protect protein from interfacial stress during ultrafiltration/diafiltration (UF/DF) process.
  • Case study: Application of HPβCD in protein formulation during UF/DF process 
    • Concentration of HPβCD was maintained throughout UF/DF process
    • HPβCD showed improved protein recovery and reduction in particle formation
  • Potential application of HPβCD in protein UF/DF process and formulation

Shiqi Hong, Senior biopharma scientist , Roquette