Dry Granulation Process Development- Flexible Manufacturing

3/16/2021 13:50 - 14:25

This presentation will cover application of Flexible Manufacturing (FM) through system modelling in dry granulation (roller compaction) process development.

Key points in presentation will be:

  • Role of Modelling in FM
  • Rational for system modelling application in OSD product and process development: Enabling FM in QbD Framework
  • Challenges in delivering FM
  • Case study examples of FM:
    • Case study 1: Clearing perception: “Modelling in FM is Expensive”
    • Case study 2: Application of System modelling in dry granulation for an immediate release oral solid tablet development
    • Case study 3- Applications of modeling approach for targeted experiments as part of QbD

Ranjit Dhenge, Investigator R&D, GlaxoSmithKline