Powder Characterization for Small Molecule Formulation – understanding the Particle-Powder-Processability Interface

3/15/2021 11:45 - 12:20

Processability issues in development of oral solid dosage forms are often triggered by drug substance variability or scale-up effects. In this context, we need predictive and discriminating analytical methods to select both the right formulation and the right process. Powder rheological and as well as mechanical properties are not assessed at all or at least standardized methods are missing. Therefore, we need to characterize the drug substances, excipients and powder blends in an appropriate manner to better understand how we can use the data to optimize particle morphology and predict processability.

Carolin Riehl, Principal Scientist | Lab Head Drug Delivery & Innovation, Merck