- Dextran-based nanogels are prepared and quantitatively loaded by making use of electrostatic interactions between the gel and the API.
- After loading, API is covalently conjugated inside the gel to prevent premature release upon administration.
- Intracellular release is triggered by reduction of the covalent bond between API and the nanogel.
- Above concept was successfully applied in cancer immunotherapy in vitro and in vivo (animal models).
Rene van Nostrum, Associate professor, Utrecht University