Nanogels for the Intracellular Delivery of Proteins and Peptides

3/11/2020 14:40 - 15:15

  • Dextran-based nanogels are prepared and quantitatively loaded by making use of electrostatic interactions between the gel and the API.
  • After loading, API is covalently conjugated inside the gel to prevent premature release upon administration.
  • Intracellular release is triggered by reduction of the covalent bond between API and the nanogel.
  • Above concept was successfully applied in cancer immunotherapy in vitro and in vivo (animal models).

Rene van Nostrum, Associate professor, Utrecht University