Aggregation Propensity and Beneficial Solution Conditions in Antibody Formulations from a Thermodynamic Perspective

3/11/2020 14:40 - 15:15

Protein aggregation is caused by the molecular interactions of all components in solution. We developed a thermodynamics based approach to predict beneficial solution conditions taking the competition for water by a specific excipient, as well as the molecular interactions of the proteins in the presence of excipients into account. This allows predicting a first estimate on aggregation propensity induced by the respective excipients and thus enables a first choice of preferential excipients, which give beneficial solution conditions, with a minimum of experimental effort. Furthermore, synergetic excipient combinations as well as their concentrations can be identified using this approach.

Dr. Christoph Brandenbusch, Group Leader , TU Dortmund