- Hydrophobic ion pairing as a key to success
- Lessons learned from in vivo studies with various peptides
- Future advances in use of lipid-based nanocarriers
Within recent years lipid-based nanocarriers such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), w/o nanoemulsions and self-emulsifying drug delivery systems (SEDDS) have been discovered for oral administration of peptide drugs. Due to the formation of hydrophobic ion pairs even highly hydrophilic peptides can be incorporated in the lipophilic phase of these carrier systems. As lipid-based nanocarriers provide a protective effect towards gastrointestinal peptidases (I), exhibit high mucus permeating properties (II) and can interact with the absorption membrane favouring the systemic uptake of their payload (III), meanwhile oral bioavailability >10% can be reached. Future advances will result in even more efficient lipid-based nanocarriers.
Andreas Bernkop-Schnürch, Research Group Drug Delivery and Powder Technology, University of Innsbruck