The drug carrier technology is a valuable option to address the challenge of low solubility of APIs. At small scale, there are various ways available to load the API onto the carrier surface. However, at larger scale, challenges typically arise in process configuration and scale-up operations. A process has been developed which allows for a stable, reliable one-step loading process and up-scaling to clinical & production scale manufacturing. After the loading process, the API-loaded carrier can finally be formulated as a tablet.