Enhancing the Oral Bioavailability of Peptide and Protein by use of Functionalised Self-Emulsifying Drug Delivery Systems (f-SEDDS)

3/13/2019 16:20 - 16:55

  • Self-emulsifying drug delivery systems (SEDDS) can inherently contain permeation enhancers, which are needed for facilitating peptide and protein absorption across the gastro-intestinal epithelium.
  • Incorporating a hydrophilic protein into a lipophilic matric represents a challenged, but is achievable by complexing the protein with a lipophilic emulsifier.
  • Functionalising the SEDDS with protease inhibitors, lipase inhibitors and mucus enhancing/permeating molecules has shown feasible and will incorporate the desired functionality into the SEDDS (f-SEDDS)