Reactive Twin-Screw Melt Extrusion in Drug Delivery

3/12/2019 11:05 - 11:40

Two case studies to illustrate the reactive between drug and excipients during twin-screw melt extrusion to improve the quality attributes of melt extruded amorphous solid dispersions. In the case of meloxicam, the presence of meglumine improves the chemical stability of meloxicam and enhances its dissolution rate.  In the case of naproxen, the presence of meglumine enhances its physical stability of naproxen and enhances its dissolution rate.