The industry predicts that 10-15% of large molecules (biologics) are sensitive to silicone. With the logarithmic rise in biologic molecules in the pipeline, there is a technical need for alternative packages that are free of silicone. Gore has commercialized a silicone free, PTFE-based fluoropolymer encased plunger that enables BARE glass syringes for sensitive large molecules (biologic and conjugate vaccines). This technology eliminates silicone oil, cross-linked silicone, baked-on silicone from the primary package. Data will be presented to show the logarithmic reduction in particles and more consistent injection time across aging conditions. Eliminating the silicone also removes a significant root cause of protein aggregation and conjugated vaccine precipitation.