Importance of Establishing the Stability of Drug-Loaded Nanoparticles

3/12/2019 16:15 - 16:50

To allow targeting of drugs by nanoparticles and triggered release at the site of action, one must ensure that drugs are stably encapsulated before reaching the target site. Usually change in pharmacokinetics and biodistribution are the prime outcome parameters to indicate stability of drug-loaded nanoparticles. However, to prevent excessive use of animals, reliable in vitro measurements are required that carefully predict in vivo stability. We will show that asymmetric flow-field flow fractionation (AF4) may do the trick. Furthermore, we will show examples of ways to improve stability and enable triggered release of drug-loaded polymer micelles.