Understanding Material Properties for HME Process Optimization in ASD Formulations

3/11/2019 16:15 - 16:50

  • Demonstrate connection between ASD thermodynamic properties and HME manufacturing process
  • Application drug/polymer phase diagram as a tool for HME risk assessment
  • Demonstrate correlation between drug/polymer phase diagram, drug load, rheology, and HME process.
  • Correlating drug product CQA (residual crystallinity, chemical/thermal stability) to drug/polymer phase diagram and HME process parameters

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