Simplifying Tablet Formulation Strategies with Avicel® SMCC and METHOCEL™ DC2

Excipients play an important role for the development of streamlined and improved production processes like direct compression and continuous manufacturing of tablets.
Avicel® SMCC is a silicified microcrystalline cellulose derived from co-processing MCC and colloidal silicon dioxide (SiO2). The co-processing yields in a high-functional excipient that exhibits performance attributes unmatched by a simple blend of MCC and SiO2 like optimum flow, superior compactability, and excellent binding properties. It is therefore the binder of choice for direct compression and continuous manufacturing.
METHOCEL™ DC2 is a pure Hypromellose for sustained release matrix tablets which was engineered by designing the particles morphology to improve flow without the use of additives or additional granulation steps.
In case studies the benefits of Avicel® SMCC and METHOCEL™ DC2 for enhanced productive processes for immediate and sustained release oral solid dosage forms are shown.