Dr. Esther Jacobs is an Associate Principal Scientist in Advanced Drug Delivery at AstraZeneca, Cambridge. She specializes in enabling oral delivery for poorly soluble and beyond Rule of 5 molecules, with expertise in amorphous solid dispersions (ASDs), lipid based formulations (LBFs), nanocrystals, and hot melt extrusion. At AstraZeneca she leads cross functional formulation strategies from early discovery through early clinical development, She holds a PhD in Pharmaceutical Sciences from Queen’s University Belfast on drug delivery using HME produced amorphous polymeric nanoparticles.