Polymer-Based Excipients in Drug Delivery: Solubility Enhancement Technology for Hydrophobic APIs

3/23/2022 12:25 - 12:55

Encapsulation technology is one of several solutions that address the low water solubility and bioavailability of hydrophobic active pharmaceutical ingredients. Vitamin E TPGS and poly(amino acids) are polymer-based amphiphilic surfactants capable of loading small hydrophobic molecules for use as drug delivery systems. Vitamin E TPGS is a safe FDA-approved pharmaceutic adjuvant that has already found multiple applications over the past 70 years as a water-soluble source of vitamin E, solubilizer or antioxidant. Poly(amino acids) are tailor-made polymers composed of amino acid units with interesting biocompatibility and biodegradability properties. These polymers are attracting increasing interest, especially for their use in nanomedicine.

Thomas Delacroix, R&D Director , PMC Isochem