Peptide Nanomaterials for Drug Delivery: A Preliminary Study of Diphenylalanine

3/23/2022 14:45 - 15:15

Peptides are interesting biomaterials whose physicochemical properties can be tuned precisely through the design of amino acid sequence. For example, diphenylalanine is a short peptide that readily forms nanotubes and microtubes upon solidification from the dissolved state. Our preliminary study shows that the diphenylalanine microtubes can effectively be loaded (loading capacity up to approx. 20%) with the model molecule, Rhodamine B, whose chemical structure is similar to doxorubicin. Future studies will focus on more nanomaterials derived from peptides of different amino acid sequence for drug delivery purposes.

Wenqian Chen, Assistant Professor , National University of Singapore