Solvent-Free Material Processing for the Development of Drug Delivery Systems Using Supercritical Carbon Dioxide (scCO2)

3/22/2022 12:25 - 12:55

Carbon dioxide (CO2) is the most commonly used supercritical fluid because of its relatively mild operating conditions (31.1°C and 72.8 bar) and easily tuneable properties. Moreover, the ability of CO2 to act as a solvent, solute and plasticiser has made it highly desirable in the field of excipient processing, particle formation and drug encapsulation. The dissolution of CO2 is known to affect glass transition or melting temperature of numerous polymers and fats. This presentation provides an overview of the applications of scCO2 primarily as a solute or plasticiser and how it can be employed to manipulate excipients properties to develop various pharmaceutically important systems. The presentation includes examples of melting point depression caused by the dissolution of scCO2 in the crystalline matrix, solvent-free preparation of drug cyclodextrin complexes, drug loading in organic and inorganic excipients and formation of pharmaceutical salts amongst others.
The application of scCO2 provides an excellent green platform for the preparation of drug delivery systems which can either completely avoid the need of the organic solvents or reduce their usage during processing. These types of processing strategies are important not only from the environmental perspective but can be crucial to address concerns related to the residual solvents in the final dosage form.
Bio Dr Vivek Trivedi is a pharmacist by training who has several years of experience in both the industry and academia. He worked in Dr Reddy’s labs after ethe completion of his undergraduate qualification before enrolling to study MSc in Pharmaceutical Science. He worked as a development scientist in Phoqus Pharmaceutical Ltd after completing his masters where he worked on developing novel formulations using Phoqus’ electrostatic dry powder deposition technology. He returned to the university to undertake a PhD in 2007 on the topic of the development of novel oral drug delivery systems for biomolecules. He started his academic career as a lecturer in formulation science in the University of Greenwich, where he stayed until April 2019. He then moved to the University of Kent where is currently employed as a senior lecturer in drug delivery. Dr Trivedi's research is centred around two areas: solubility improvement of BCS II drugs and oral delivery of biomolecules. His interests strongly revolve around the use of green processing methods, in particular, supercritical carbon dioxide to develop suitable strategies for drug delivery. He developed a platform known as Solid Core Drug Delivery System (SCDDS) for the oral delivery of biomolecules which entails immobilisation of biomolecules onto inorganic host followed by a coating with suitable excipients to target them to lower intestine and provide sustained release. His interests also include the application of scCO2 to manipulate physical properties of drugs and excipients to prepare cyclodextrin-drug complexes, perform solvent-free coating, and obtain drug loading in organic and inorganic excipients. He has attracted funding from various industrial sources as well as European Union, Royal Society and Royal Society of Chemistry to conduct research in areas summarised above.

Vivek Trivedi, Lecturer in Drug Delivery, Medway School of Pharmacy, University of Kent