The 3D printing (3DP) process patented in 1986; however, only in the last decade has been used for medical applications, as well as being utilized in the fields of bio-fabrication and pharmaceutical printing. 3DP or Additive Manufacturing (AM) is a family of technologies that implement layer-by-layer processes to fabricate physical prototypes, based on a Computer Aided Design (CAD) model. 3DP permits the fabrication of high degrees of complexity with great reproducibility, in a fast and cost-effective fashion, offers a new paradigm for the direct manufacture of individual dosage forms, and has the potential to allow variations in their size and geometry varied to control dose and release behaviour. 3DP thus offers the perfect innovative manufacturing route to address critical capability gaps hindering the widespread exploitation of personalised drug delivery systems and medical implants. Ideally, the design and fabrication of such systems should be customised to each individual patient. This talk will focus in the manufacturing of drug delivery systems & medical implants (e.g. vascular grafts, meshes, microneedles) using innovative 3DP and bioprinting technologies. The studies include in-house prepared Bio-inks using natural or synthetic polymers, and preparation of drug-loaded or empty filaments by hot-melt extrusion (HME).