Trehalose and Sucrose: Essential components of Platform Biopharma Formulations and Covid 19 Applications

3/21/2022 10:15 - 10:45

  • Commercial Biotherapeutics Stabilized with Trehalose and Sucrose
  • Key Issues in Biopharma Formulation Development
  • Essential components of a “Platform Biopharma Formulation”
  • Examples for utilizations and functionalities of Sucrose and Trehalose in Covid 19 related formulations/vaccines and techniques (m-RNA, Viral vectors, mAbs etc.)
  • Understanding important physicochemical properties of Trehalose and Sucrose
    • Instability of sucrose at low pH – free glucose, protein glycation
    • Phase transition and crystallization of trehalose
    • Importance of Control of Glucose levels in Sucrose as well as Trehalose
  • Purity, Quality, Consistency in Pfanstiehl’s Trehalose and Sucrose
    • β-glucans in sucrose – interference with endotoxins
    • Trace metal specifications for Sucrose and Trehalose
    • Upcoming compendial changes
  • Advantages of Trehalose over Sucrose
  • Pfanstiehl’s Biopharma Stabilization Portfolio incld. newly launched L-Arginine and L-Histidine base and HCl
  • Conclusions

Christian Lotz, General Manager EMEA, Pfanstiehl GmbH