Supercharging Proteins with Multivalent Excipients is a Much More Effective Strategy for Increasing Aggregation Resistance than Using Mutagenesis

Robin Curtis is a Senior Lecturer in the School of Chemical Engineering and Analytical Science at the University of Manchester.  Before joining Manchester, he did post-doctoral work supervised by Michael W. Deem at Rice University and University of California at Los Angeles, and completed his PhD under the supervision of John M. Prausnitz and Harvey W. Blanch at University of California at Berkeley.  He is a trained biochemical engineering with expertise in molecular approaches to understand protein solution behaviour directly relevant to downstream bioprocessing unit operations and liquid formulations.   Current projects focus on developing novel approaches for predicting shelf stability of biopharmaceuticals using chemical stress, investigating methods for supercharging proteins to enhance their resistance against aggregation, and understanding the relationship between dilute solution properties and concentrated solution behaviour, such as rheology, phase separation, and particle formation.