Oral administration is the most convenient and preferred way of taking drugs. However, apart from a few exceptions, oral administration is currently not an option for biologics. The use of absorption enhancers has limitations, including safety issues and its applicability to a narrow range of biologics. Different delivery strategies are therefore urgently needed. Nanomedicine-based approaches have promising potential for oral biologics, though one has to apply a deep understanding of the gastrointestinal tract physiology and barriers in the design of nanosystems for oral delivery of biologics. In this talk, I will summarise the latest findings from my lab on nanomedicine-based approaches, including bovine milk exosomes, and their potential for oral delivery of biologics.